Changelog

Posts in category "Release"

Posts are organized into categories for ease of navigation:

Algorithm - developments to the interpretation algorithm implemented in Python.
Announcement - general news related to the Molecular Oncology Almanac.
Annual newsletters - annual newsletters that recap updates.
Database - changes and additions to the underlying knowledge base.
Release - aggregated release notes from GitHub releases (serving as the project changelog).

Database release 2026-05-07 Categories: Database, Release
This Release contains updates to the draft version of the database. Concept mappings to RxNorm, SNOMED, and OMOP are now present for all curated therapies. We additionally curate an approval for imlunestrant from the European Medicines Agency, as well as another for belzutifan from both the European Medicines Agency and Food and Drug Administration.
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Database release 2026-04-09 Categories: Database, Release
This release contains updates to the draft version of the database. EGFR TKD activating variants was introduced as a biomarker and associated with regulatory approvals from the European Medicines Agency (EMA) and Health Canada (HC). No additional genomic knowledge statements were added with this release, though several were modified.
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Database release 2026-03-05 Categories: Database, Release
This release contains updates to the draft version of the database with FDA precision oncology approvals from February 2026. Specifically, indications and derived relationships were updated for Braftovi (encorafenib), Hernexeos (zongertinib), and Keytruda (pembrolizumab).
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Database release 2026-02-05 Categories: Database, Release
This release contains updates to the draft version of the database with FDA precision oncology approvals for Akeega. Additionally, the Organizations table was merged into the Agents table.
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Database release 2025-12-26 Categories: Database, Release
This release contains updates to the current and draft versions of the database with FDA precision oncology approvals from October, November, and December 2025.
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Algorithm release 0.8.5 2025-10-24 Categories: Algorithm, Release
This release utilizes the v.2025-02-07 version of the MOAlmanac database. Cancer Gene Census is also no longer required to run moalmanac. The interpreter version was increased to 0.8.5.
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Algorithm release 0.8.4 2025-10-17 Categories: Algorithm, Release
This release utilizes the v.2025-02-07 version of the MOAlmanac database. Both COSMIC and ExAC are now no longer required to run moalmanac. The interpreter version was increased to 0.8.4.
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Database release 2025-10-02 Categories: Database, Release
This release contains updates to the current and draft versions of the database with FDA and EMA precision oncology approvals from September 2025.
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Algorithm release 0.8.3 2025-09-11 Categories: Algorithm, Release
This release utilizes the v.2025-02-07 version of the MOAlmanac database. It includes a fix to a bug that prevented HTML report generation. Specifically, in rare circumstances, the columns sensitive_score_bin_map, resistance_score_bin_map, and prognostic_score_bin_map were not added to the data object for actionable variants, which are used to sort report tables.
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Database release 2025-09-04 Categories: Database, Release
This release contains updates to the current and draft versions of the database with FDA oncology approvals from June, July, and August 2025. The change log local to this repository has been removed and pointers now direct to news.moalmanac.org. Release notes will also continue to be available through this repository’s Releases.
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Algorithm release 0.8.2 2025-06-25 Categories: Algorithm, Release
This release utilizes the v.2025-02-07 release of the underlying MOAlmanac database. The codebase now supports Python 3.13 with no warnings produced, although we will continue officially using 3.12 for the time being.
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Database release 2025-06-12 Categories: Database, Release
Updated current and draft version of the database with FDA oncology approvals from May and June, thus far, 2025.
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Database release 2025-05-01 Categories: Database, Release
Updated current and draft version of the database with FDA oncology approvals from April 2025.
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Database release 2025-03-06 Categories: Database, Release
In this release, we have normalized therapy_name values to NCI thesaurus (#40) and merged an initial version of the next version of our database (#36), that aims to follow with GA4GH’s Genomic Knowledge Standards for the database schema (Read more here).
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Database release 2025-02-07 Categories: Database, Release
Added entries:
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Algorithm release 0.8.1 2025-02-07 Categories: Algorithm, Release
This release utilizes version 2025-02-07 of the underlying moalmanac database and contains changes from several pull requests: #32, #33, #35, and #36.
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Database release 2025-01-11 Categories: Database, Release
This database release contains relevant FDA Oncology updates from March 2025.
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Algorithm release 0.8.0 2024-12-10 Categories: Algorithm, Release
This release utilizes the v.2024-12-05 version of the underlying database and contains changes from several pull requests: #27, #28, #29, #30, #31.
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Database release 2024-12-05 Categories: Database, Release
This release contains 1,001 approved relationships.
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Database release 2024-11-07 Categories: Database, Release
This release contains 997 approved relationships.
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Algorithm release 0.7.2 2024-10-25 Categories: Algorithm, Release
This release utilizes the v.2024-10-03 release of the underlying MOAlmanac database and otherwise fixes two bugs present in Release 0.7.1. This release incorporates pull requests https://github.com/vanallenlab/moalmanac/pull/23 and https://github.com/vanallenlab/moalmanac/pull/24.
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Database release 2024-10-03 Categories: Database, Release
This release contains 993 approved relationships.
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Algorithm release 0.7.1 2024-10-01 Categories: Algorithm, Release
This release utilizes the v.2024-04-11 release of the underlying MOAlmanac database and primarily focuses on adding logging to MOAlmanac and refactoring the codebase to remove the datasources/ directory from the application folder. It incorporates changes from two pull requests: https://github.com/vanallenlab/moalmanac/pull/21 and https://github.com/vanallenlab/moalmanac/pull/22.
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Database release 2024-09-05 Categories: Database, Release
This release contains 989 approved relationships.
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Database release 2024-07-11 Categories: Database, Release
Added entries:
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Database release 2024-06-06 Categories: Database, Release
Added entries:
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Algorithm release 0.6.0 2024-05-31 Categories: Algorithm, Release
This release utilizes the v.2024-04-11 release of the underlying MOAlmanac database and primarily focuses on supporting Python 3.12. It incorporates changes from two pull requests: https://github.com/vanallenlab/moalmanac/pull/18 and https://github.com/vanallenlab/moalmanac/pull/19.
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Database release 2024-04-11 Categories: Database, Release
Added entries:
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Database release 2024-03-07 Categories: Database, Release
Added entries:
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Database release 2024-02-01 Categories: Database, Release
Added entries:
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Database release 2024-01-11 Categories: Database, Release
Added entries:
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Algorithm release 0.5.0 2024-01-05 Categories: Algorithm, Release
This release utilizes the v.2023-11-09 release of the underlying MOAlmanac database and incorporates changes from three pull requests: #15: Added AIP to hereditary cancers gene list, #16: Update db nov 2023, and #17: Revise handling of COSMIC mutational signatures.
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Database release 2023-12-07 Categories: Database, Release
Added entries:
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Database release 2023-11-09 Categories: Database, Release
This month’s data release features recent FDA approvals, updates of mutational signatures from version 2 to 3.4, updates to the source fields for several citations, removal of several entries, revising format of all clinical guideline citations, and the publication_date field has been populated for all current database records.
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Database release 2023-10-05 Categories: Database, Release
Added entries:
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Database release 2023-09-07 Categories: Database, Release
Added entries:
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Database release 2023-07-06 Categories: Database, Release
Added entries:
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Algorithm release 0.4.6 2023-04-13 Categories: Algorithm, Release
This release utilizes the v.2023-04-06 release of the underlying MOAlmanac database. It incorporates changes from two pull requests: #13 and #14.
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Database release 2023-04-06 Categories: Database, Release
Added entries:
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Algorithm release 0.4.5 2023-03-10 Categories: Algorithm, Release
This release utilizes the v.2023-02-02 release of the underlying MOAlmanac database. It incorporates changes from three pull requests: changing the underlying MOAlmanac database from TinyDB to JSON (#9), adding a simplified input option to run MOAlmanac (#10), and updating datasources (#11).
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Database release 2023-02-02 Categories: Database, Release
In this release, we add two recent precision oncology approvals from the FDA regarding ER signaling inhibition in two cancer types.
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Database release 2023-01-05 Categories: Database, Release
In this release, we add two recent precision oncology approvals from the FDA.
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Database release 2022-12-01 Categories: Database, Release
In this release, we have removed neoantigen burden as a cataloged feature type and combined Silencing with Knockdown feature types. We additionally expanded upon fields required for each feature type within our S.O.P.
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Database release 2022-10-06 Categories: Database, Release
Added entries:
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Database release 2022-09-08 Categories: Database, Release
Added entries:
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Database release 2022-08-04 Categories: Database, Release
Added entries:
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Database release 2022-07-07 Categories: Database, Release
Revised entries:
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Database release 2022-03-03 Categories: Database, Release
Revised entries:
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Algorithm release 0.4.2 2022-02-15 Categories: Algorithm, Release
This release utilizes the v.2021-02-04 release of the underlying MOAlmanac database.
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Database release 2021-11-04 Categories: Database, Release
Added entries:
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Database release 2021-10-07 Categories: Database, Release
Added entries:
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Database release 2021-09-02 Categories: Database, Release
The following assertions sourced from recent FDA approvals were added to the Molecular Oncology Almanac in this release -
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Database release 2021-06-03 Categories: Database, Release
The following recent FDA approvals were added to the Molecular Oncology Almanac in this release -
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Database release 2021-05-06 Categories: Database, Release
The following changes were made to the Molecular Oncology Almanac in this release -
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Algorithm release 0.4.1 2021-05-01 Categories: Algorithm, Release
This release utilizes the v.2021-02-04 release of the underlying MOAlmanac database.
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Database release 2021-02-04 Categories: Database, Release
In addition to the content changes listed below, this release added a therapeutic strategy (therapy_strategy) for all sensitive and resistance relationships.
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Database release 2020-12-03 Categories: Database, Release
Added entries:
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Database release 2020-11-12 Categories: Database, Release
This release focuses on FDA approvals since March 2020. In addition to the following changes, the citation style for all FDA approved associated have been updated to match American Medical Association (AMA) style formatting.
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