News

Posts are organized into categories for ease of navigation:

• Algorithm - developments to the interpretation algorithm implemented in Python.
• Announcement - general news related to the Molecular Oncology Almanac.
• Annual newsletters - annual newsletters that recap updates.
• Database - changes and additions to the underlying knowledge base.
• Release - aggregated release notes from GitHub releases (serving as the project changelog).

• Re-developing our schema to align with GA4GH standards 2025-03-06 Categories:  Announcement, Database

  We are in the process of refactoring and updating moalmanac db to align with GA4GH’s Variant Annotation Specification (va-spec) and Categorical Variant Representation Specification (Cat-VRS). Both of these specifications are in development and are following the GA4GH Genomic Knowledge Standards (GKS) Maturity Model. As components of each specification moves from draft to trial and to normative maturity we will update our schema to align with their recommendations. This version of the database is under active development and, if you have any thoughts, comments, concerns, or suggestions, please contact us!

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• Database release 2025-03-06 Categories:  Database, Release

  In this release, we have normalized therapy_name values to NCI thesaurus (#40) and merged an initial version of the next version of our database (#36), that aims to follow with GA4GH’s Genomic Knowledge Standards for the database schema (Read more here).

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• Database release 2025-02-07 Categories:  Database, Release

  Added entries:

  • (FDA) ALK rearrangements and sensitivity to ensartinib for the treatment of adult patients with non-small cell lung cancer.
  • (FDA) BRAF p.V600E and sensitivity to encorafenib in combination with cetuximab and mFOLFOX6 for the treatment of patients with colorectal cancer.
  • (FDA) KRAS p.G12C and sensitivity to panitumumab in combination with sotorasib for the treatment of adult patients with metastatic colorectal cancer.
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• Algorithm release 0.8.1 2025-02-07 Categories:  Algorithm, Release

  This release utilizes version 2025-02-07 of the underlying moalmanac database and contains changes from several pull requests: #32, #33, #35, and #36.

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• Database release 2025-01-11 Categories:  Database, Release

  This database release contains relevant FDA Oncology updates from March 2025.

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